Davinder Jassal

About

I was born in Thompson, Manitoba, Canada, obtained an International Baccalaureate Degree at Sisler High School in Winnipeg, and graduated from the University of Manitoba with an MD in 1998. i completed a residency in Internal Medicine at the University of Manitoba from 1998-2001 and a residency in Adult Cardiology at Dalhousie University in Halifax, Nova Scotia, Canada. Subsequently, I completed a clinical and research fellowship in Cardiac Imaging specializing in echocardiography, CT, and MRI at Massachusetts General Hospital, Harvard Medical School, Boston, MA. I joined the Section of Cardiology, Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences at the University of Manitoba in 2006 as an Academic Clinician Scientist, where half of his time is devoted to patient care in CCU and cardiac imaging and the other half devoted to translational research in the field of Cardio-Oncology. I currently am a Full Professor of Medicine, Radiology, and Physiology and Pathophysiology. As Head of the Section of Cardiology in the Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, at the University of Manitoba, I am also the Principal Investigator of the Cardiovascular Imaging Laboratory as a member of the Institute of Cardiovascular Sciences.

Research Interests

My research focuses on the complementary use of multimodality cardiovascular imaging in the non-invasive assessment of heart failure syndromes. Using a combination of echocardiography (ultrasound of the heart), cardiac CT (computed tomography), and CMR (cardiac MRI), the Cardiovascular Imaging Laboratory at St. Boniface Albrechtsen Research Centre is dedicated to translational research in the fields of Cardio-Oncology, Women’s Heart Health, and Sudden Cardiac Death.

Awards

2018 – Canadian Society of Clinical Investigation/Royal College of Physicians and Surgeons of Canada Henry Friesen Award and Lecture
2016 – Doctors Manitoba Scholastic Award for scholarly activity in the health professionals
2015 – Morley Lertzman Teaching Award, Department of Internal Medicine, University of Manitoba
2015 – Research Manitoba Mid-Career Research Award
2015 – Manitoba Medical Student’s Association Med I Teaching Innovation Award

Research Funding

Canadian Agriculture Partnership/Ag Action Manitoba 2019-2022. Title: Flaxseed prevents broken hearts in breast cancer (CANFLAX) study. CancerCare Manitoba RIOH Summer Studentship funding 2019. Title: Flaxseed prevents broken hearts in breast cancer (CANFLAX) study. Canadian Cancer Society/CIHR Grant Innovation (Co-Applicant) 2018-2020. Title: Exercise to prevent AnthraCycline-based Cardio-Toxicity (EXACT 2.0) in individuals with breast cancer. Molson Women’s Heart Health Research Competition 2018-2020. Title: Reducing cardiovascular risk in women with breast cancer. Catholic Health Corporation of Manitoba Studentship funding 2018 and CancerCare Manitoba RIOH Summer Studentship funding 2018. Title: Flaxseed in the mitigation of anthracycline and trastuzumab mediated cardiotoxicity (FANTAM) study. Jewish Foundation of Manitoba Women’s Endowment Fund 2017-2018. Title: The art of detecting broken hearts in women with breast cancer. University Collaborative Research Program (UCRP) 2018-2020. Title: Role of cardiac CT for risk stratification in the marathon population. CancerCare Manitoba Operating Grant 2017-2019. Title: Flaxseed in the mitigation of anthracycline and trastuzumab mediated cardiotoxicity (FANTAM) study. Diagnostic Services Manitoba 2017-2019. Title: Scleraxis as a biomarker for cardiac fibrosis in hypertrophic cardiomyopathy. CIHR Operating grant (Co-applicant) 2015-2020. Title: The role of FGF2 isoforms in cardiac remodelling. Research Manitoba Mid-Career Research Grant 2015-2019. Title: The prophylactic role of renin-angiotensin system antagonists in the prevention of Avastin and Sutent mediated cardiotoxicity. CancerCare Manitoba Operating Grant 2015-2017. Title: The art of preventing broken hearts in colorectal and renal cell cancer. University Research Grants Program 2014-2015. Title: Avastin and Sutent mediated Cardiotoxicity study (ASICS). CancerCare Manitoba Operating Grant 2013-2015. Title: The impact of Doxorubicin and Trastuzumab on cardiac cytoarchitecture and function: insights into the prevention of chemotherapy mediated cardiotoxicity in breast cancer.

Publications

2019 - Morissette MP, Susser SE, Stammers AN, Moffatt TL, Wigle JT, Wigle TJ, Netticadan T, Premecz S, Jassal DS , O’Hara KA, Duhamel TA. Exercise-induced increases in the expression and activity of cardiac sarcoplasmic reticulum calcium ATPase 2 is attenuated in AMPKα2 kinase-dead mice. Can J Physiol Pharmacol. 2019 Jun 25:1-10. Abdelfatah N, Chen R, Duff HJ, Seifer CM, Buffo I, Huculak C, Clarke S, Clegg R, Jassal DS, Gordon PMK, Ober C; Care4Rare Canada Consortium, Frosk P, Gerull B. Characterization of a Unique Form of Arrhythmic Cardiomyopathy Caused by Recessive Mutation in LEMD2. JACC Basic Transl Sci. 2019 Apr 29;4(2):204-221. Chu K, Asselin CY, Buffo I, Lane M, Ludwig L, Jassal DS, Schantz D. The role of cardiac magnetic resonance imaging in severe anorexia nervosa. Cureus. 2019 Mar 11;11(3):e4229. Luu J, Boston-Griffiths E, Zhu A, Jassal DS, Minhas K. Colossal left ventricular apical thrombus. Clin Case Rep. 2019 Mar 3;7(4):846-848. Mozolevska V, Schwartz A, Cheung D, Goyal V, Shaikh B, Dingman B, Kim E, Mittal I, Asselin CY, Edel AL, Ravandi A, Thliveris J, Singal PK, Czaykowski P, Jassal DS. Role of renin-angiotensin system antagonists in the prevention of bevacizumab and sunitinib mediated cardiac dysfunction. Am J Physiol Heart Circ Physiol. 2019 Mar1;316(3):H446-H458. Nohla LF, Abdelmoneim SS, Villarraga R, Kohli M, Grothey A, Bordun KA, Cheung M, Best R, Cheung D, Huang R, Barros-Gomes S, Pitz M, Singal PK, Jassal DS, Mulvagh SL. Echocardiographic assessment for the detection of cardiotoxicity due to vascular endothelial growth factor inhibitor therapy in metastatic renal cell and colorectal cancers. J Am Soc Echocardiogr. 2019 Feb;32(2):267-276. Koleini N, Santiago JJ, Nickel BE, Sequiera GL, Wang J, Fandrich RR, Jassal DS, Dhingra S, Kirshenbaum LA, Cattini PA, Kardami E. Elimination or neutralization of endogenous high molecular weight FGF2 mitigates Doxorubicin induced cardiotoxicity. Am J Physiol Heart Circ Physiol. 2019 Feb 1;316(2):H279-H288. Ho J, Toleva O, Jassal DS, Khoo C. Atypical Cardiac Manifestations of Systemic Myositis. J Clin Rheumatol. 2019 Jan 18. doi: 10.1097/RHU.0000000000000992. Yeang C, Hasanally D, Que X, Hung MY, Stemankovic A, Chan D, Chaudhary R, Margulets V, Edel AL, Hoshijima M, Gu Y, Bradford W, Dalton N, Miu P, Cheung DYC, Jassal DS, Pierce GN, Peterson KL, Kirshenbaum LA, Witztum JL, Tsimikas S, Ravandi A. Reduction of myocardial ischemia-referfusion injury by inactivating oxidized phospholipids. Cardiovasc Res. 2019 Jan 1;115(1):179-189.

Patients & Visitors

Health Professionals

Students & Trainees

Education